SF6-11st in NFC WestLevi's Stadium
17 gamesESPN
ESPN
| # | Player | POS | AGE | HT | WT | EXP | BORN |
|---|---|---|---|---|---|---|---|
| 11 |  Brandon AiyukOut | WR | 28 | 6' 0" | 200 lbs | 6 yr | Rocklin, CA |
| 26 |  Kaelon Black | RB | 25 | 5' 9" | 208 lbs | 0 yr | Virginia Beach, VA |
| 64 |  Jake Brendel | C | 34 | 6' 4" | 299 lbs | 9 yr | Plano, TX |
| 75 |  Connor Colby | G | 23 | 6' 5" | 309 lbs | 2 yr | Cedar Rapids, IA |
| 84 |  Brandin Cooks | WR | 33 | 5' 10" | 189 lbs | 13 yr | Stockton, CA |
| 4 |  Jacob Cowing | WR | 25 | 5' 9" | 171 lbs | 3 yr | Maricopa, AZ |
| 69 |  Enrique Cruz Jr. | OT | 23 | 6' 5" | 313 lbs | 0 yr | Chicago, IL |
| 5 |  Mike EvansQuestionable | WR | 33 | 6' 5" | 231 lbs | 13 yr | Galveston, TX |
| 89 |  Luke Farrell | TE | 29 | 6' 5" | 250 lbs | 6 yr | Perry, OH |
| 29 |  Jordan James | RB | 22 | 5' 9" | 208 lbs | 2 yr | Nashville, TN |
| 10 |  Mac Jones | QB | 28 | 6' 3" | 220 lbs | 6 yr | Jacksonville, FL |
| 44 |  Kyle Juszczyk | FB | 35 | 6' 2" | 235 lbs | 14 yr | Medina, OH |
| 3 |  Christian Kirk | WR | 29 | 5' 11" | 200 lbs | 9 yr | Scottsdale, AZ |
| 85 |  George Kittle | TE | 33 | 6' 4" | 250 lbs | 10 yr | Norman, OK |
| 76 |  Vederian Lowe | OT | 27 | 6' 6" | 320 lbs | 5 yr | Rockford, IL |
| 23 |  Christian McCaffreyQuestionable | RB | 30 | 5' 11" | 210 lbs | 10 yr | Castle Rock, CO |
| 68 |  Colton McKivitz | OT | 30 | 6' 6" | 301 lbs | 7 yr | Jacobsburg, OH |
| 58 |  Jarrett Patterson | G | 27 | 6' 4" | 310 lbs | 4 yr | Laguna Hills, CA |
| 77 |  Dominick Puni | G | 26 | 6' 5" | 313 lbs | 3 yr | Saint Charles, MO |
| 13 |  Brock Purdy | QB | 26 | 6' 1" | 220 lbs | 5 yr | Gilbert, AZ |
| 14 |  Kurtis Rourke | QB | 26 | 6' 4" | 220 lbs | 1 yr | Oakville, ON |
| 19 |  Deebo Samuel Sr.Questionable | WR | 30 | 6' 0" | 215 lbs | 8 yr | Inman, SC |
| 89 |  Jack Stoll | TE | 28 | 6' 4" | 245 lbs | 6 yr | Lone Tree, CO |
| 81 |  Malik Turner | WR | 30 | 6' 2" | 202 lbs | 5 yr | Springfield, IL |
| 17 |  Jordan Watkins | WR | 24 | 5' 11" | 196 lbs | 2 yr | Louisville, KY |
| 71 |  Trent Williams | OT | 38 | 6' 5" | 320 lbs | 17 yr | Longview, TX |
| 9 |  Brayden Willis | TE | 26 | 6' 4" | 240 lbs | 4 yr | Arlington, TX |
| 74 |  Carver Willis | OT | 24 | 6' 5" | 303 lbs | 0 yr | Durango, CO |
| # | Player | POS | AGE | HT | WT | EXP | BORN |
|---|---|---|---|---|---|---|---|
| 48 |  Tatum Bethune | LB | 25 | 6' 1" | 230 lbs | 3 yr | Miami, FL |
| 97 |  Nick BosaQuestionable | DE | 29 | 6' 4" | 266 lbs | 8 yr | Fort Lauderdale, FL |
| 27 |  Ji'Ayir Brown | S | 26 | 5' 11" | 202 lbs | 4 yr | Trenton, NJ |
| 24 |  Ashtyn Davis | S | 30 | 6' 1" | 205 lbs | 7 yr | Santa Cruz, CA |
| 53 |  Jaden Dugger | LB | 22 | 6' 4" | 240 lbs | 0 yr | Pittsburgh, PA |
| 51 |  Luke GiffordQuestionable | LB | 31 | 6' 3" | 243 lbs | 8 yr | Lincoln, NE |
| 41 |  Jalen Graham | LB | 25 | 6' 3" | 220 lbs | 3 yr | Detroit, MI |
| 0 |  Renardo Green | CB | 25 | 6' 0" | 186 lbs | 3 yr | Orlando, FL |
| 57 |  Dre GreenlawNews | LB | 29 | 6' 0" | 230 lbs | 8 yr | Fayetteville, AR |
| 93 |  Gracen Halton | DT | 22 | 6' 2" | 293 lbs | 0 yr | San Diego, CA |
| 94 |  Romello Height | DE | 25 | 6' 2" | 239 lbs | 0 yr | Dublin, GA |
| 25 |  Jack Jones | CB | 28 | 5' 11" | 175 lbs | 5 yr | Long Beach, CA |
| 47 |  Khalid Kareem | DE | 28 | 6' 4" | 268 lbs | 4 yr | Detroit, MI |
| 2 |  Deommodore Lenoir | CB | 27 | 5' 10" | 200 lbs | 6 yr | Los Angeles, CA |
| 6 |  Malik Mustapha | S | 24 | 5' 10" | 206 lbs | 3 yr | Charlotte, NC |
| 33 |  Siran Neal | S | 32 | 6' 0" | 206 lbs | 9 yr | Eufaula, AL |
| 92 |  Osa Odighizuwa | DT | 28 | 6' 2" | 294 lbs | 6 yr | Portland, OR |
| 59 |  Ogbo Okoronkwo | LB | 31 | 6' 2" | 253 lbs | 9 yr | Houston, TX |
| 28 |  Ephesians Prysock | CB | 23 | 6' 3" | 196 lbs | 0 yr | Canyon Country, CA |
| 36 |  Marques SigleQuestionable | S | 24 | 5' 11" | 199 lbs | 2 yr | Omaha, NE |
| 20 |  Upton StoutQuestionable | CB | 24 | 5' 9" | 181 lbs | 2 yr | Houston, TX |
| 96 |  James Thompson Jr. | DT | 24 | 6' 6" | 308 lbs | 0 yr | Cincinnati, OH |
| 55 |  Sebastian Valdez | DT | 24 | 6' 3" | 301 lbs | 1 yr | Spring Valley, CA |
| 49 |  Garret WallowQuestionable | LB | 27 | 6' 2" | 230 lbs | 6 yr | New Orleans, LA |
| 54 |  Fred Warner | LB | 29 | 6' 3" | 230 lbs | 9 yr | San Marcos, CA |
| 56 |  Keion White | DE | 27 | 6' 5" | 290 lbs | 4 yr | Garner, NC |
| 98 |  Mykel Williams | DE | 22 | 6' 5" | 267 lbs | 2 yr | Columbus, GA |
| # | Player | POS | AGE | HT | WT | EXP | BORN |
|---|---|---|---|---|---|---|---|
| 18 |  Eddy Pineiro | PK | 31 | 5' 11" | 190 lbs | 9 yr | Miami, FL |
| 15 |  Corliss Waitman | P | 31 | 6' 2" | 210 lbs | 4 yr | Milton, FL |
| 46 |  Jon Weeks | LS | 40 | 5' 10" | 242 lbs | 17 yr | Bethpage, NY |
| # | Player | POS | AGE | HT | WT | EXP | BORN |
|---|---|---|---|---|---|---|---|
| 95 |  Alfred CollinsInjured Reserve | DT | 25 | 6' 5" | 332 lbs | 2 yr | Bastrop, TX |
| 50 |  Andrew Farmer IIInjured Reserve | DE | 26 | 6' 4" | 250 lbs | 2 yr | Jacksonville, FL |
| 29 |  Darrick ForrestInjured Reserve | S | 27 | 5' 11" | 200 lbs | 5 yr | Columbus, OH |
| 31 |  Isaac GuerendoOut | RB | 26 | 6' 0" | 221 lbs | 3 yr | Clayton, IN |
| 22 |  Nate HobbsInjured Reserve | CB | 27 | 6' 0" | 195 lbs | 6 yr | Louisville, KY |
| 59 |  Mikail KamaraInjured Reserve | DE | 25 | 6' 1" | 265 lbs | 0 yr | Ashburn, VA |
| 45 |  Nick MartinInjured Reserve | LB | 24 | 5' 11" | 221 lbs | 2 yr | Texarkana, TX |
| 91 |  Sam OkuayinonuInjured Reserve | DT | 28 | 6' 1" | 269 lbs | 4 yr | Lowell, MA |
| 1 |  Ricky PearsallInjured Reserve | WR | 26 | 6' 1" | 189 lbs | 3 yr | Chandler, AZ |
| 62 |  Austen PleasantsInjured Reserve | OT | 29 | 6' 7" | 330 lbs | 2 yr | Ironton, OH |
| 11 |  Demarcus RobinsonInjured Reserve | WR | 32 | 6' 1" | 202 lbs | 11 yr | Fort Valley, GA |
| 7 |  De'Zhaun StriblingInjured Reserve | WR | 23 | 6' 2" | 207 lbs | 0 yr | Kapolei, HI |
| 88 |  Jake TongesInjured Reserve | TE | 27 | 6' 4" | 240 lbs | 4 yr | Los Gatos, CA |
| 78 |  Brett TothQuestionable | C | 30 | 6' 6" | 304 lbs | 7 yr | Charleston, SC |
| 99 |  C.J. WestInjured Reserve | DT | 24 | 6' 1" | 316 lbs | 2 yr | Chicago, IL |
| 63 |  Nick ZakeljInjured Reserve | OT | 27 | 6' 6" | 316 lbs | 4 yr | Broadview Heights, OH |
| # | Player | POS | AGE | HT | WT | EXP | BORN |
|---|---|---|---|---|---|---|---|
| 67 |  Isaac AlarconPractice Squad | OT | 28 | 6' 7" | 320 lbs | 1 yr | Monterrey, Mexico |
 Vincent Anthony Jr.Practice Squad | DE | 22 | 6' 6" | 260 lbs | 0 yr | Durham, NC | |
 Brandon CodringtonPractice Squad | CB | 25 | 5' 9" | 185 lbs | 3 yr | Raleigh, NC | |
| 43 |  Khalil DinkinsPractice Squad | TE | 24 | 6' 4" | 226 lbs | 0 yr | Wexford, PA |
| 61 |  Viliami Fehoko Jr.Practice Squad | DE | 26 | 6' 4" | 267 lbs | 2 yr | East Palo Alto, CA |
| 18 |  Wesley GrimesPractice Squad | WR | 22 | 6' 2" | 194 lbs | 0 yr | Raleigh, NC |
 McKinnley JacksonPractice Squad | DT | 24 | 6' 2" | 330 lbs | 3 yr | Lucedale, MS | |
| 50 |  Naquan JonesPractice Squad | DT | 28 | 6' 3" | 313 lbs | 7 yr | Evanston, IL |
| 35 |  Sincere McCormickPractice Squad | RB | 26 | 5' 8" | 204 lbs | 3 yr | Converse, TX |
| 66 |  Drake NugentPractice Squad | C | 25 | 6' 1" | 300 lbs | 1 yr | Lone Tree, CO |
| 84 |  Will PaulingPractice Squad | WR | 23 | 5' 9" | 183 lbs | 0 yr | Chicago, IL |
 Foster SarellPractice Squad | OT | 28 | 6' 7" | 315 lbs | 5 yr | Graham, WA | |
 Xavier SmithPractice Squad | WR | 29 | 5' 9" | 180 lbs | 3 yr | Haines City, FL | |
| 38 |  Jalen StromanPractice Squad | S | 23 | 6' 1" | 203 lbs | 0 yr | Bristow, VA |
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